Rahul Jangle
B. Pharm., M. Pharm. (Currently Ph. D. Student)
Email: ce08rd.jangle@ictmumbai.edu.in
| Education Details | ||
Course |
Institute/University |
Year of Passing |
| B. Pharm. |
University Institute of Chemical Technology, UICT, Mumbai | 2002 |
| M. Pharm. | Poona College of Pharmacy, Bharati Vidyapeeth, Pune | 2006 |
| Ph. D. Tech. Bioprocess Technology |
University Institute of Chemical Technology, UICT, Mumbai | - |
Abstract of Ph. D. Thesis:
PROCESS DEVELOPMENT FOR LIPOSOMAL DRUG PRODUCTS
Liposome technology has established itself as an important model system in past three decades in different basic sciences and as a viable alternative in several industrial applications. Advances in liposome design are leading to new applications for the delivery of new biotechnology products, such as recombinant proteins and cloned genes which are very sensitive to degradation. Slow research and cost limitations resulted many lacunas in the existing technology starting from selection of proper row materials to formulating final stabilized dried product with maximum drug entrapment. Research is focused on complete process development and obtaining final dried product with better entrapment and shelf life.
Liposomes are microscopic vesicles composed of a bilayer of phospholipids or any similar amphipathic lipids. Research work includes screening for alternatives to organic solvents, designing the system to enhance surface area for film formation. Screening of wide variety of cheaper lipids is today’s need of this technology. Research will be carried out with varying drug to phospholipids to cholesterol ratios. Screening for additives like cholesterol, various antioxidants will also be considered. Development of sterically stabilized liposomes by different polymers coating. Effect of lipid vesicle size, temperature, vacuum, pH, buffers and solvent system on drug entrapment will be studied. One most crucial aspect to be studied is the process to develop a suitable, short and economic drying technology for obtaining completely dried liposomal product with its potency retention.
Economic industrial scale implementation of the process is the ultimate aim of the research work so that it will benefit to the human health and society at large.