Vivek Chaughule

---

B. Pharm ., M. Tech. BPT (Currently Ph. D. Student)
Email: ce07va.chaughule@ictmumbai.edu.in

Education Details
Course	Institute/University	Year of Passing
B. Pharm	University of Pune	2005
M. Tech. Bio Process Technology	University Institute of Chemical Technology, UICT, Mumbai	2007
Ph. D. Tech. Bio Process Technology	University Institute of Chemical Technology, UICT, Mumbai	-

Abstract of Ph. D. Thesis:

STUDIES IN FORMULATION STABILIZATION AND DRYING OF BIOLOGICAL PRODUCTS

Use of proteins as therapeutic entity opens up many avenues in the field of biotechnology. But the biggest single issue in dealing with proteins is the instability of the proteins themselves. Once the protein is purified and concentrated to the desired possible extent, the manufacturer's main objective is to maintain its activity over the period of time. Proteins are highly organized, complex structures that must maintain structural and chemical integrity to function properly. Many manufacturing methods can jeopardize this by exposing proteins to potentially damaging conditions, such as aqueous/organic interfaces, elevated temperatures, vigorous agitation, hydrophobic surfaces, and detergents. Some proteins retain their activity under operational conditions for weeks or even months, whereas, most do not. Hence, the relatively small quantity of active proteins is often formulated using stabilizers, preservatives, salts and the diluents. Drying has been used for the stabilization of various heat-sensitive proteins such as industrial and therapeutic enzymes. Thus, drying and formulation are important processing steps for the stability of proteins.
Work:
* Characterization of the Therapeutic protein in terms of heat sensitivity, glass transition temperature and so on.
* Selection of proper drying systems for the protein.
* To study the drying techniques and the optimization of process parameters.
* Study on formulation of therapeutic protein.
* Study on the scale up and cost effectiveness of the complete separation process.